de Beer SB, van Bergen LA, Keijzer K, Rea V, Venkataraman H, Guerra CF, Bickelhaupt FM, Vermeulen NP, Commandeur JN, Geerke DP.
The role of protein plasticity in computational rationalization studies on regioselectivity in testosterone hydroxylation by cytochrome P450 BM3 mutants.
Curr. Drug. Metab. 2012; 13: 155-166

Venkataraman H, de Beer SB, van Bergen LA, van Essen N, Geerke DP, Vermeulen NP, Commandeur JN.
A single active site mutation inverts stereoselectivity of 16-hydroxylation of testosterone catalyzed by engineered cytochrome P450 BM3.
Chembiochem. 2012; 13: 520-523

Boerma JS, Vermeulen NP, Commandeur JN.
Application of CYP102A1M11H as a tool for the generation of protein adducts of reactive drug metabolites.
Chem. Res. Toxicol. 2011; 24: 1263-1274

Park BK, Boobis A, Clarke S, Goldring CE, Jones D, Kenna JG, Lambert C, Laverty HG, Naisbitt DJ, Nelson S, Nicoll-Griffith DA, Obach RS, Routledge P, Smith DA, Tweedie DJ, Vermeulen N, Williams DP, Wilson ID, Baillie TA.
Managing the challenge of chemically reactive metabolites in drug development.
Nat. Rev. Drug. Discov. 2011; 10: 292-306

van Leeuwen JS, Orij R, Luttik MA, Smits GJ, Vermeulen NP, Vos JC.
Subunits Rip1p and Cox9p of the respiratory chain contribute to diclofenac-induced mitochondrial dysfunction.
Microbiology 2011; 157: 685-694

Vasanthanathan P, Olsen L, Jørgensen FS, Vermeulen NP, Oostenbrink C.
Computational prediction of binding affinity for CYP1A2-ligand complexes using empirical free energy calculations.
Drug. Metab. Dispos. 2010; 38: 1347-1354

Hritz J, de Ruiter A, Oostenbrink C.
Impact of plasticity and flexibility on docking results for cytochrome P450 2D6: a combined approach of molecular dynamics and ligand docking.
J. Med. Chem. 2008; 51: 7469-7477

Damsten MC, Commandeur JN, Fidder A, Hulst AG, Touw D, Noort D, Vermeulen NP.
Liquid chromatography/tandem mass spectrometry detection of covalent binding of acetaminophen to human serum albumin.
Drug. Metab. Dispos. 2007; 35: 1408-1417

Kool J, van Liempd SM, van Rossum H, van Elswijk DA, Irth H, Commandeur JN, Vermeulen NP.
Development of three parallel cytochrome P450 enzyme affinity detection systems coupled on-line to gradient high-performance liquid chromatography.
Drug. Metab. Dispos. 2007; 35: 640-648

van Vugt-Lussenburg BM, Stjernschantz E, Lastdrager J, Oostenbrink C, Vermeulen NP, Commandeur JN.
Identification of critical residues in novel drug metabolizing mutants of cytochrome P450 BM3 using random mutagenesis.
J. Med. Chem. 2007; 50: 455-461

de Graaf C, Vermeulen NP, Feenstra KA.
Cytochrome p450 in silico: an integrative modeling approach.
J. Med. Chem. 2005; 48: 2725-2755

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