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Division of Organic Chemistry

Research profile

Romano Orru      Lammertsma, Koop      Tom Grossmann

Prof. dr. ir. Romano Orru             Prof. dr. Koop Lammertsma           Prof. dr. Tom Grossmann

The Division of Organic Chemistry consists of two chairs: Organic and Organometallic Chemistry and Synthetic & Bio-organic Chemistry. 

Organic and Organometallic Chemistry

The Organic and Organometallic Chemistry research group op Prof. Koop Lammertsma researches new synthetic methods, reagents and catalysts, and develops reactive intermediates aimed at the sustainable use of chemicals. The mechanistic understanding of reactions and catalytic processes is pursued experimentally and computationally. The fundamental research focuses on: 

  • Developing a spectrum of organophosphorus reagents as enabling tools in organic syntheses.
  • Advancing organometallic complexes for asymmetric catalysis and metathesis.
  • Synthesizing and understanding the mode of operation of (non-)natural peptides and metalloenzymes.
  • Creating silicates as chiral organic anions. 

The work of this research group has led to the uncovering of new synthetic building blocks, the development of new classes of organometallic complexes for catalytic purposes, and is providing detailed insights into the complex functioning of metalloenzymes.


Synthetic & Bio-organic Chemistry

The Synthetic & Bio-organic Chemistry research group of Prof. Romano Orru focuses on the development of highly efficient, asymmetric synthetic methodologies and their application to the synthesis of diverse, biologically relevant compounds, with an emphasis on atom and resource efficiency. Three main areas of interest can be distinguished:

  • Rational design and development of flexible novel multicomponent reactions (MCRs).

  • Use of biocatalysts for the production of enantiopure building blocks for MCR.

  • Development of asymmetric versions of MCRs and related processes using biocatalysis and/or homogeneous catalysis. 

The group's efforts in this area have resulted in the development of several novel MCRs furnishing valuable heterocycles. Another goal is the integration of the group’s successes in MCR chemistry and biocatalysis in approaches towards the total synthesis of complex natural products.

The following subgroups are associated with this chair:

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